RESUMEN
BACKGROUND: Ensovibep (MP0420) is a designed ankyrin repeat protein, a novel class of engineered proteins, under investigation as a treatment of SARS-CoV-2 infection. OBJECTIVE: To investigate if ensovibep, in addition to remdesivir and other standard care, improves clinical outcomes among patients hospitalized with COVID-19 compared with standard care alone. DESIGN: Double-blind, randomized, placebo-controlled, clinical trial. (ClinicalTrials.gov: NCT04501978). SETTING: Multinational, multicenter trial. PARTICIPANTS: Adults hospitalized with COVID-19. INTERVENTION: Intravenous ensovibep, 600 mg, or placebo. MEASUREMENTS: Ensovibep was assessed for early futility on the basis of pulmonary ordinal scores at day 5. The primary outcome was time to sustained recovery through day 90, defined as 14 consecutive days at home or place of usual residence after hospital discharge. A composite safety outcome that included death, serious adverse events, end-organ disease, and serious infections was assessed through day 90. RESULTS: An independent data and safety monitoring board recommended that enrollment be halted for early futility after 485 patients were randomly assigned and received an infusion of ensovibep (n = 247) or placebo (n = 238). The odds ratio (OR) for a more favorable pulmonary outcome in the ensovibep (vs. placebo) group at day 5 was 0.93 (95% CI, 0.67 to 1.30; P = 0.68; OR > 1 would favor ensovibep). The 90-day cumulative incidence of sustained recovery was 82% for ensovibep and 80% for placebo (subhazard ratio [sHR], 1.06 [CI, 0.88 to 1.28]; sHR > 1 would favor ensovibep). The primary composite safety outcome at day 90 occurred in 78 ensovibep participants (32%) and 70 placebo participants (29%) (HR, 1.07 [CI, 0.77 to 1.47]; HR < 1 would favor ensovibep). LIMITATION: The trial was prematurely stopped because of futility, limiting power for the primary outcome. CONCLUSION: Compared with placebo, ensovibep did not improve clinical outcomes for hospitalized participants with COVID-19 receiving standard care, including remdesivir; no safety concerns were identified. PRIMARY FUNDING SOURCE: National Institutes of Health.
Asunto(s)
Tratamiento Farmacológico de COVID-19 , Adulto , Proteínas de Repetición de Anquirina Diseñadas , Método Doble Ciego , Humanos , Proteínas Recombinantes de Fusión , SARS-CoV-2 , Resultado del TratamientoAsunto(s)
Accidentes por Caídas/prevención & control , Técnicos Medios en Salud/educación , Seguridad del Paciente , Administración de la Seguridad/organización & administración , Accidentes por Caídas/estadística & datos numéricos , Técnicos Medios en Salud/legislación & jurisprudencia , Unidades Hospitalarias , Humanos , Investigación en Evaluación de Enfermería , Grupo de Enfermería/organización & administración , Proyectos PilotoRESUMEN
Se estudiaron sesenta casos de mujeres embarazadas que cursaron con muerte fetal, durante un periodo de ocho meses en el año de 1994, en el Hospital Regional "Santa Teresa" de Comayagua determinándose una frecuencia de esta patología durante el período estudiado de 41.5 por cada mil nacimientos vivos, resultado notablemente superior a nivel mundial. Establecemos una relación significativa con una serie de variables asi como, algunas recomendaciones en relación a este problema en la población rural en edad reproductiva concerniente a la importancia de control prenatal y otros
